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WDR5 WIN site inhibitor C6

CAS No. ——

WDR5 WIN site inhibitor C6( —— )

Catalog No. M17068 CAS No. ——

WDR5 WIN site inhibitor C6 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 0.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    WDR5 WIN site inhibitor C6
  • Note
    Research use only, not for human use.
  • Brief Description
    WDR5 WIN site inhibitor C6 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 0.1 nM.
  • Description
    WDR5 WIN site inhibitor C6 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 0.1 nM; inhibits leukemia cell lines in vitro (MV4:11 cell GI50=3.2 uM), rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    498.383
  • Molecular Formula
    C25H22Cl2FN5O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    N-(3,4-dichlorobenzyl)-3-(6-fluoro-2-methylpyridin-3-yl)-5-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.
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